Unlike, say, vitamin C, however, the human body is, under normal circumstances, capable of producing all the cholesterol it needs. A zero-cholesterol dietĭietary cholesterol comes exclusively from animal-derived foods, so if you don’t eat much or any dairy, eggs, meat, or fish, chances are you have a low or zero intake of cholesterol. ![]() And, given that older age is one of the potential causes underlying low cholesterol, it’s always smart to get your lipids checked regularly and not just accept your doc’s outdated one-size-fits-all ideas about statins. The whole point of statins is to reduce cholesterol, but there’s real concern that statins are prescribed willy-nilly, especially for older folks. In these cases, a diet including cholesterol-rich foods can help, or you may be advised to take a cholesterol supplement. In some pregnancies, a mutation in DHCR7 can lead to spontaneous abortion.Įven if your genetic tests show a mutation affecting DHCR7, you may only have mild reductions in cholesterol synthesis. The DHCR7s gene is essential for proper cholesterol synthesis, and if someone has a mutation in this gene, they may have serious abnormalities at birth and ongoing challenges. More commonly, mutations in the DHCR7 gene cause very low cholesterol and can lead to Smith-Lemli-Opitz syndrome (SLOS). Mutations in these genes almost always results in high cholesterol levels, but in a few cases, mutations may result in a total deficiency of PCSK9 and LDL-C levels in the range of 15 mg/dl without any reported adverse effects. These include LDLR, PCSK9, and APOB, which affect cholesterol clearance. Genetic polymorphisms and SLOSĪ whole host of genes are involved in cholesterol synthesis, absorption, and metabolism. Let’s briefly look at each of these and offer a few quick solutions. Genetic polymorphisms and conditions such as SLOS.So, what are the 5 most common causes of high cholesterol? Chances are they’re: ![]()
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